Welcome to the Evolutionary RNA Designer (ERD) webserver !
The function of an RNA sequence is highly dependent on its three-dimensional conformation which is referred to as RNA tertiary structure. Since the prediction or experimental determination of these structures is very difficult, so many works focus on the problems associated with the RNA secondary structure. This web server uses the ERD program to design RNA sequences that fold into a given target RNA secondary structure, i.e. the RNA sequences whose minimum free energy (MFE) structure is as similar as possible to the target structure.